Jacob & Esau and Tainted Forgotten count as two players, will crash the game if they join after 3 players are already in. Curse of Labyrinth/XL floors and Curse of Blind are bad, restart if it happens on first floor. Diplopia and pandoras box work the same, Moving box is worth a try. Then use your extra players to hit the spikes 7 times, if you don't get at least one good item, just restart -Spawning items in boss rooms will give you an item for every player that is alive, I used The Stars? card in a boss room with the Tarot Cloth, and it spawned 4 boss items, that could be picked up 4 times each! (16 extra items from one card). Tips for runs: -If you wanna get OP fast, restart over and over until you have a sacrifice room next to you. then just mop up the small stuff afterwards. And keep an eye out for Monster Manual after you break the game, then use it over and over to get a Super Bandage girl! Normal completion marks: My Ideal route goes as follows: -Boss Rush -Hush -Cathedral (If going for Mega Satan, Gives you more goodies) -Kill ?/lamb -Exit room and go kill Mega Satan -If lucky, enter void and fight Delirium, if not, just gotta do hush > void one more time. (It can take a very long time to find these items in the first shop, and it can be frustrating, if you find OP items like ipecac or something, just try to keep going, some of my best runs were because I found echo chamber in the third room) Also, don't take lil baggy, it changes cards into pills. If you have a lot of extra Eden tokens, it can be way faster to keep restarting until he gets one of these. Gnawed Leaf + orbital/auto attack familiar + patience. For me, It would roll Supper into Echo Chamber. Know what items you have unlocked, it skips items you don't have. Spindown Dice, use it to get the other items. It xan ve a little tricky to get this break going, but it should lead to unlimited pickups. D20/D Infinity, find a store with lil battery Clear the waves without picking up coins, reroll coins, only open chests and pick up nickles/dimes/keys if needed for chests. Just keep restarting until you find any of the following -Echo Chamber (easiest way to break the game, expecially if you get two of diamonds) -Blank Card, 2 of diamonds, lil battery in the shop. Previously mentioned items -unlock all characters, (your second controller can unlock the lost with missing poster, so you don't have to end your run) -Unlock Greedier -Complete Greedier as soon as possible (I personally recommend doing this early because the item pools will be smaller and hopefully have a better chance of finding game breaking items if unlocked) -Finish the rest of the marks -Challenges Greedier mode: There are no extra items/coins spawned for playing co-op, however, you do get benefits from the other players, like isaacs D6, or other pickups/items. Do daily challenges every day, you need to complete 7, and attempt 30. I recommend completing the game in this loose order: -Always play on Hard or Greedier (if unlocked). (if they are dead they will revive at the end of the boss fight and give you four rewards, this does not work for the first boss of XL floors). Also, you get 4 rewards at the end of boss fights if all four players are alive. The benifits of CO-OP is that each character that you select gets completion marks regardless if they are alive or not. (Sounds like a lot but this game can take up to 1,000 hours of natural gameplay) I will assuming you at least have the Polaroid and Negative, and I will not be describing every process like how to unlock the lost/forgotten/tainted bois Key Items to unlock: -Isaac's D6 -Red Key (for tainted characters) -D20 -Blank Card -Echo Chamber -Spindown Dice (you don't need all of these, but they make Greed soooo much easier) The main strategy I use for the base game takes advantage of the CO-OP system that was added with Repentance. The reason I decided to cheese this game was because I have already beat this game, and there's two stacks on Xbox now! For this you will need 3-4 controllers, moderate skill/knowledge of the game, and around 200 hours of your time. *Before I say anything, Quick Restart is LB + RB + LS + RS* Hello! I figured I post all my tips and tricks on how I beat this game pretty quickly and easily! If you have any additional tips that I don't mention, post them here! If you are just starting The Binding of Isaac for the first time, this guide is not for you! Go enjoy the game a little before you do it this way.
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